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Article

Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers.

World journal of surgical oncology - 29 Jul 2021

He Yuting, Yu Xiao, Zhang Menggang, Guo Wenzhi

Abstract excerpt

BACKGROUND: 5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m5C regulators and the outcomes of modified nucleobases in RNAs. METHODS: Based on The Cancer Genome Atlas (TCGA) database, we uncovered that mutations and copy number variations (CNVs) of m5C regulatory genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34325709
DOI: 10.1186/s12957-021-02342-y
PMCID: PMC8323224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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