Article

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

2018-04-02

Abstract excerpt

<h4>Summary</h4> Protein glycosylation is a widespread post-translational modification. The first committed step to the lipid-linked glycan used for this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15). Missense DPAGT1 variants cause congenital myasthenic syndrome and congenital disorders of glycosylation. In addition, naturally-occurring bactericidal n...

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Literature Corpus work: 35ecfc12-f076-510e-abb8-8c6280234826
DOI: 10.1101/291278

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