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Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics

27 Apr 2022

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The rise and dissemination of glycopeptide antibiotic (GPA)-resistant pathogens in healthcare settings fuel efforts to discover GPAs that can overcome resistance. Members of the type V subclass of GPAs can evade common GPA resistance mechanisms and offer promise as new drug leads. We characterize five new type V GPAs─rimomycin-A/B/C and...

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PMID: 35647273
DOI: 10.1021/acscentsci.1c01389

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