Article

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

2021-01-28

Abstract excerpt

The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the genetic and structural basis for SARS-CoV-2 neutralization, we determined the structures of two human monoclonal antibodies COV2-2196 and COV2-2130 1 , which form the basis of the investigational antibody cocktail AZD7442, in complex with th...

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Literature Corpus work: c474cb14-7778-560b-bbd6-d7e32a2bf9ce
DOI: 10.1101/2021.01.27.428529

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