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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

20 Mar 2021

Abstract excerpt

. Despite these similarities, class members bind both RBD-up and -down conformations of the spike, with a subset of antibodies using elongated CDRH3s to recognize glycan N343 on a neighboring RBD-a quaternary interaction accommodated by an increase in RBD separation of up to 12 Å. The VH1-2 antibody class, thus, uses modular recognition encoded by modular genetic elements to effect potent neutralization, with the...

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PMID: 33794145
DOI: 10.1016/j.celrep.2021.108950

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