Article
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.
Nature microbiology - 1 Oct 2021
Dong Jinhui, Zost Seth J, Greaney Allison J, Starr Tyler N, Dingens Adam S, Chen Elaine C, Chen Rita E, Case James Brett, Sutton Rachel E, Gilchuk Pavlo, Rodriguez Jessica, Armstrong Erica, Gainza Christopher, Nargi Rachel S, Binshtein Elad, Xie Xuping, Zhang Xianwen, Shi Pei-Yong, Logue James, Weston Stuart, McGrath Marisa E, Frieman Matthew B, Brady Tyler, Tuffy Kevin M, Bright Helen, Loo Yueh-Ming, McTamney Patrick M, Esser Mark T, Carnahan Robert H, Diamond Michael S, Bloom Jesse D, Crowe James E
Abstract excerpt
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies-AZD8895 and AZD1061-which form the basis of the investigational antibody cocktail AZD7442, in complex with the receptor-binding domain (RBD) of SARS-CoV-2 to define the genetic and structural...
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