Article

A novel humanized mouse model to study the function of human cutaneous memory T cells <i>in vivo</i> in human skin

2018-12-07

Abstract excerpt

Human skin contains a population of memory T cells that support tissue homeostasis and provide protective immunity. The study of human memory T cells is often restricted to in vitro studies and to human PBMC serving as primary cell source. Because the tisse environment impacts the phenotype and function of memory T cells, it is crucial to study these cells within their tissue. Here we utilized immunodeficient NOD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e6002c7-7dac-59f7-b57c-88ee833a28a9
DOI: 10.1101/490060

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel humanized mouse model to study the function of human cutaneous memory T cells <i>in vivo</i> in human skinDOI 10.1101/490060Read

Circulating CD4+ memory T cells give rise to a CD69+ resident memory T cell population in non-inflamed human skinSemantic proximity Read

Transcriptional profiling and single-cell chimerism analysis identifies human tissue resident T cells in the human skin after allogeneic stem cell transplantationSemantic proximity Read

Memory regulatory T cells reside in human skin.Semantic proximity Read

Functional heterogeneity of human skin-resident memory T cells in health and disease.Semantic proximity Read

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host diseaseSemantic proximity Read

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.Semantic proximity Read

Tissue-intrinsic γδ T cells critically regulate Tissue-Resident Memory CD8 T cellsSemantic proximity Read

Persistence of CD8+ skin-resident memory T cells in mice requires TCR signalingSemantic proximity Read

Tissue-Resident Memory T Cells in Antifungal Immunity.Semantic proximity Read

Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype.Semantic proximity Read

Human CD127 negative ILC2s show immunological memorySemantic proximity Read

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.Semantic proximity Read