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Article

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.

Science translational medicine - 18 Mar 2015

Watanabe Rei, Gehad Ahmed, Yang Chao, Scott Laura L, Teague Jessica E, Schlapbach Christoph, Elco Christopher P, Huang Victor, Matos Tiago R, Kupper Thomas S, Clark Rachael A

Abstract excerpt

The skin of an adult human contains about 20 billion memory T cells. Epithelial barrier tissues are infiltrated by a combination of resident and recirculating T cells in mice, but the relative proportions and functional activities of resident versus recirculating T cells have not been evaluated in human skin. We discriminated resident from recirculating T cells in human-engrafted mice and lymphoma patients using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25787765
DOI: 10.1126/scitranslmed.3010302
PMCID: PMC4425193

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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