Article

Inhibition of Atrial Natriuretic Peptide Clearance Reduces Myocardial Fibrosis and Improves Cardiac Function in Diabetic Rats

2024-08-03

Abstract excerpt

<h4>Background</h4> Natriuretic peptides (NP) exert pleotropic effects through the recruitment of cGMP-signaling pathways depending on their bioavailability which is regulated by clearance receptors and peptidases. Here, we tested the hypothesis that increasing myocardial bioavailability of NP has a beneficial effect on heart failure. We studied the effects of a mutated NP, MANP, resistant to neprilysin in a mode...

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Literature Corpus work: 2b3a11fd-8747-56e4-aae3-ffbaf210d9cc
DOI: 10.1101/2024.08.01.606125

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