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Article

Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes.

Cells - 5 Oct 2021

Widiapradja Alexander, Kasparian Ainsley O, McCaffrey Samuel L, Kolb Lauren L, Imig John D, Lacey Jessica L, Melendez Giselle C, Levick Scott P

Abstract excerpt

Reduced levels of the sensory nerve neuropeptide substance P (SP) have been reported in the diabetic rat heart, the consequence being a loss of cardioprotection in response to ischemic post-conditioning. We considered whether this loss of SP also predisposes the heart to non-ischemic diabetic cardiomyopathy in the form of fibrosis and hypertrophy. We report that diabetic Leprdb/db mice have reduced serum SP and...

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Share to Cardiomegaly
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor for Advanced Glycation End Products

Share to Receptors, Leptin

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Source

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Identifiers

PMID: 34685639
DOI: 10.3390/cells10102659
PMCID: PMC8534147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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