Article

The Orphan Nuclear Receptor Nr4a1 Contributes to Interstitial Cardiac Fibrosis via Modulation of Cardiac Fibroblast and Macrophage Phenotype

2024-09-06

Abstract excerpt

<title>Abstract</title> The orphan nuclear receptor Nr4a1 has complex biological functions and has been implicated in numerous diseases, including cardiovascular disease. While protective in atherosclerosis and myocardial ischemia, Nr4a1 has been shown to cause cardiac fibrosis in non-ischemic adverse remodelling of the heart. However, mechanisms underlying these actions are still poorly understood. Accordingl...

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Literature Corpus work: 13611eac-747d-5864-ac4f-5f0672e16f03
DOI: 10.21203/rs.3.rs-4630863/v1

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