Article

Distinct transcriptional programs of SOX2 in different types of small cell lung cancers

2019-11-28

Abstract excerpt

SOX2 is an oncogene in human small cell lung cancer (SCLC), an aggressive neuroendocrine (NE) tumor. However, the roles of SOX2 in SCLC remain unclear, and strategies to selectively target SOX2 in SCLC cells have not yet been established. We herein demonstrated that SOX2 is involved in NE differentiation and tumorigenesis in cooperation with ASCL1, a lineage-specific transcriptional factor, in the classical subtyp...

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Literature Corpus work: 6e405477-369b-52ea-9d0c-6ba1b7366250
DOI: 10.1101/857144

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