Article
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
Nature genetics - 1 Oct 2012
Rudin Charles M, Durinck Steffen, Stawiski Eric W, Poirier John T, Modrusan Zora, Shames David S, Bergbower Emily A, Guan Yinghui, Shin James, Guillory Joseph, Rivers Celina Sanchez, Foo Catherine K, Bhatt Deepali, Stinson Jeremy, Gnad Florian, Haverty Peter M, Gentleman Robert, Chaudhuri Subhra, Janakiraman Vasantharajan, Jaiswal Bijay S, Parikh Chaitali, Yuan Wenlin, Zhang Zemin, Koeppen Hartmut, Wu Thomas D, Stern Howard M, Yauch Robert L, Huffman Kenneth E, Paskulin Diego D, Illei Peter B, Varella-Garcia Marileila, Gazdar Adi F, de Sauvage Frederic J, Bourgon Richard, Minna John D, Brock Malcolm V, Seshagiri Somasekar
Abstract excerpt
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis. Here, we obtained exome, transcriptome and copy-number alteration data from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLC and lymphoblastoid cell lines. We also obtained data for 4 primary tumors and 23 SCLC cell lines. We identified 22 significantly mutated genes in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.