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Article

Distinct transcriptional programs of SOX2 in different types of small cell lung cancers.

Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2020

Tenjin Yuki, Matsuura Kumi, Kudoh Shinji, Usuki Shingo, Yamada Tatsuya, Matsuo Akira, Sato Younosuke, Saito Haruki, Fujino Kosuke, Wakimoto Joeji, Ichimura Takaya, Kohrogi Hirotsugu, Sakagami Takuro, Niwa Hitoshi, Ito Takaaki

Abstract excerpt

SOX2 is recognized as an oncogene in human small cell lung cancer (SCLC), which is an aggressive neuroendocrine (NE) tumor. However, the role of SOX2 in SCLC is not completely understood, and strategies to selectively target SOX2 in SCLC cells remain elusive. Here, we show, using next-generation sequencing, that SOX2 expressed in the ASCL1-high SCLC (SCLC-A) subtype cell line is dependent on ASCL1, which is a...

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PMID: 32801334
DOI: 10.1038/s41374-020-00479-0

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