Article

Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism

1990-01-01

Abstract excerpt

ABSTRACT Treatment of C57B1/6J mice with three successive doses of all-trans retinoic acid (28 mg kg-1 body weight) on 8 day, 6h (8d,6h), 8d,12h, and 8d,18h of gestation resulted in a high incidence (79%, 31/39 fetuses) of spina bifida with myeloschisis (spina bifida aperta) in near term fetuses. Twelve hours following the last maternal dose (9d,6h), the caudal aspects of treated embryos, were abnormal, with evers...

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Literature Corpus work: 6e2fbdab-d1c9-5074-ad47-5b389333f5da
DOI: 10.1242/dev.108.1.73

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