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What's retinoic acid got to do with it? Retinoic acid regulation of the neural crest in craniofacial and ocular development

3 Jun 2019

Abstract excerpt

Retinoic acid (RA), the active derivative of vitamin A (retinol), is an essential morphogen signaling molecule and major regulator of embryonic development. The dysregulation of RA levels during embryogenesis has been associated with numerous congenital anomalies, including craniofacial, auditory, and ocular defects. These anomalies result from disruptions in the cranial neural crest, a vertebrate-specific...

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PMID: 31157952
DOI: 10.1002/dvg.23308

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