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Disturbed apoptosis and cell proliferation in developing neuroepithelium of lumbo‐sacral neural tubes in retinoic acid‐induced spina bifida aperta in rat

5 Apr 2012

Abstract excerpt

Spina bifida is a complex congenital malformation resulting from failure of fusion in the spinal neural tube during embryogenesis. However, the cellular mechanism underlying spina bifida is not fully understood. Here, we investigated cell apoptosis in whole embryos and proliferation of neural progenitor cells in the spinal neural tube during neurulation in all-trans retinoic acid (atRA)-induced spina bifida in...

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PMID: 22504176
DOI: 10.1016/j.ijdevneu.2012.03.340

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