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Article

Valproic acid‐induced spina bifida: A mouse model

1 Feb 1992

Abstract excerpt

Prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with the formation of spina bifida aperta, meningocele, and meningomyelocele in the human. Until now, a direct relationship between VPA application and spina bifida has not been experimentally demonstrated. VPA was known only to induce exencephaly in mice, a defect of the anterior neural tube. Maximal sensitivity toward production...

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Identifiers

PMID: 1377411
DOI: 10.1002/tera.1420450208

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