Exogenous retinoic acid during gastrulation induces cartilaginous and other craniofacial defects in Fundulus heteroclitus.

doi:10.2307/1543098

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Article

Exogenous retinoic acid during gastrulation induces cartilaginous and other craniofacial defects in Fundulus heteroclitus.

The Biological bulletin - 1 Jun 1998

Vandersea M W, McCarthy R A, Fleming P, Smith D

Abstract excerpt

Embryonic levels of retinoic acid (RA) and the response of cells to RA are critical to the normal development of vertebrates. To understand the effects of RA signaling in Fundulus heteroclitus, we exposed embryos to a range of RA concentrations of 2 h during gastrulation. Embryos exposed to low c...

Topics

Animals
Body Patterning
Cartilage
Craniofacial Abnormalities
Female
Gastrula
Killifishes
Male
Phenotype
Signal Transduction
Tretinoin

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