Article

A Small-Molecule Mitochondrial Complex I Modulator Improves Behavioral and Mitochondrial Dysfunction in Schizophrenia

2026-05-21

Abstract excerpt

Weak inhibition of mitochondrial complex I (mtCI) has been shown to have neuroprotective effects in cellular and animal models of Alzheimer’s and Huntington’s diseases, at least in part by enhancing mitochondrial biogenesis and function. Mitochondrial dysfunction has also been demonstrated in schizophrenia patients and mouse models of schizophrenia. We tested whether weak inhibition of mtCI would ameliorate mitoch...

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Literature Corpus work: 6e23d208-84fc-5674-b48f-be7144ca0d41
DOI: 10.64898/2026.05.19.726440

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