Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia

14 Nov 2014

Abstract excerpt

Autophagy plays a key role in the pathophysiology of schizophrenia as manifested by a 40% decrease in BECN1/Beclin 1 mRNA in postmortem hippocampal tissues relative to controls. This decrease was coupled with the deregulation of the essential ADNP (activity-dependent neuroprotector homeobox), a binding partner of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3 β) another major constituent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Cellular transport and secretion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25484074
DOI: 10.4161/15548627.2014.984274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophreniaPMID 25484074Read ↗

Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model.Semantic proximity Read ↗

ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's DiseaseSemantic proximity Read ↗

Autophagy has a key role in the pathophysiology of schizophreniaSemantic proximity Read ↗

Autophagy and Schizophrenia: A Closer Look at How Dysregulation of Neuronal Cell Homeostasis Influences the Pathogenesis of SchizophreniaSemantic proximity Read ↗

Autophagy in Schizophrenia: A Continuum From Developmental Vulnerability to Progressive Neuronal Stress? A Scoping ReviewSemantic proximity Read ↗

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapseSemantic proximity Read ↗

Desloratadine Rescues Schizophrenia-like Phenotypes by Inhibiting the Pathogenic 5-HT2AR-PI3K/AKT/mTOR Signaling Axis.Semantic proximity Read ↗

Increased regional activity of a pro-autophagy pathway in schizophrenia as a contributor to sex differences in the disease pathologySemantic proximity Read ↗

Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330Semantic proximity Read ↗

NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathiesSemantic proximity Read ↗

Preventing clinical deterioration in the course of schizophrenia: the potential for neuroprotection.Semantic proximity Read ↗

Microglia ablation alleviates myelin-associated catatonic signs in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.