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Article

Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology.

Neoplasia (New York, N.Y.) - 1 Jul 2026

Zhu Haixia, Shao Jingjing, Wang Yaxuan, Gu Chunyan, Liu Jibin

Abstract excerpt

DNA damage response (DDR) pathways are essential for maintaining genomic integrity. Accumulating pan-cancer evidence, however, reveals that alterations within these networks act as widespread drivers of tumor initiation, progression, and therapeutic vulnerability. This review synthesizes the biological mechanisms and clinical implications of DDR defects across solid tumors. We first detail how the disruption of...

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Identifiers

PMID: 42054804
DOI: 10.1016/j.neo.2026.101315
PMCID: PMC13141633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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