Article

Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers

2026-02-06

Abstract excerpt

Loss-of-function genomic alterations in FANCA occur across multiple cancer types, yet no molecularly tailored therapies have successfully exploited this potential vulnerability. Using complementary unbiased approaches, including a genome-wide CRISPR/Cas9 loss-of-function screen and a high-throughput drug screen in isogenic cancer cell-based models, we identified Aurora kinase A (AURKA) as a reproducible synthetic...

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Literature Corpus work: bcf838ce-77f4-55fb-811f-7017cf4b58b1
DOI: 10.64898/2026.02.04.703705

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