Targeting the DNA Damage Response for Cancer Therapy

doi:10.3390/ijms242115907

Article

Targeting the DNA Damage Response for Cancer Therapy

2 Nov 2023

Abstract excerpt

Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the...

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