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Evolving DNA repair synthetic lethality targets in cancer

24 Nov 2022

Abstract excerpt

DNA damage signaling response and repair (DDR) is a critical defense mechanism against genomic instability. Impaired DNA repair capacity is an important risk factor for cancer development. On the other hand, up-regulation of DDR mechanisms is a feature of cancer chemotherapy and radiotherapy resistance. Advances in our understanding of DDR and its complex role in cancer has led to several translational DNA...

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PMID: 36420962
DOI: 10.1042/bsr20221713

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