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Article

Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network.

PloS one - 1 Jan 2012

Yabuki Munehisa, Cummings W Jason, Leppard John B, Immormino Robert M, Wood Christi L, Allison Daniel S, Gray Patrick W, Tjoelker Larry W, Maizels Nancy

Abstract excerpt

Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We have established a platform for rapid discover...

Read the complete abstract on PubMed

Topics

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Share to Antibodies, Monoclonal, Humanized
Share to Antibody Affinity
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Lac Operon

Share to Lac Repressors

Share to Streptavidin

Source

Open in PubMed Open full text

Identifiers

PMID: 22558313
DOI: 10.1371/journal.pone.0036032
PMCID: PMC3338700

Genes

FZD10
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22558313-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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