Article
Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells.
Science signaling - 14 Jan 2020
Karathanasis Christos, Medler Juliane, Fricke Franziska, Smith Sonja, Malkusch Sebastian, Widera Darius, Fulda Simone, Wajant Harald, van Wijk Sjoerd J L, Dikic Ivan, Heilemann Mike
Abstract excerpt
Ligand-induced tumor necrosis factor receptor 1 (TNFR1) activation controls nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling, cell proliferation, programmed cell death, and survival and is crucially involved in inflammation, autoimmune disorders, and cancer progression. Despite the relevance of TNFR1 clustering for signaling, oligomerization of ligand-free and ligand-activated TNFR1...
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