Article

Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power

2018-01-16

Abstract excerpt

Mutant allele frequency distributions in cancer samples have been used to estimate intratumoral heterogeneity and its implications for patient survival. However, mutation calls are sensitive to the calling algorithm. It remains unknown whether the relationship of heterogeneity and clinical outcome is robust to these variations. To resolve this question, we studied the robustness of allele frequency distributions t...

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Literature Corpus work: 6dd65204-3ef4-584f-b60f-69e55de391da
DOI: 10.1101/248435

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