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High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma

20 May 2013

Abstract excerpt

BACKGROUND: Although the presence of genetic heterogeneity within the tumors of individual patients is established, it is unclear whether greater heterogeneity predicts a worse outcome. A quantitative measure of genetic heterogeneity based on next-generation sequencing (NGS) data, mutant-allele tumor heterogeneity (MATH), was previously developed and applied to a data set on head and neck squamous cell carcinoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23696076
DOI: 10.1002/cncr.28150

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