Article

Confounding factors in assessing the enriched expression of somatic mutant allele in bulk tumor samples

2025-05-31

Abstract excerpt

Allele-specific expression (ASE) of somatic mutations can be caused by cis -activation of the mutant allele or silencing of the wildtype allele and has been investigated by examining the enrichment of mutant allele in RNA relative to DNA. Here we show that this mutation-based approach can be confounded by gene expression differences in tumor and normal cells which co-exist in most bulk tumor samples. We modeled m...

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Literature Corpus work: 8afec8eb-5f42-52f8-9b29-ee0d063eec7d
DOI: 10.1101/2025.05.27.656366

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