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Phospho-proteomic analysis of CAR-T cell signaling following activation by antigen-presenting cancer cells

2022-02-25

Abstract excerpt

Chimeric antigen receptors (CARs) are synthetic biomolecules comprised of an extracellular antigen recognition domain and intracellular signaling domains. When expressed in immune cells, CARs direct their host cells to kill diseased cells expressing the antigen recognized by the CAR. Although signaling pathways downstream of CAR activation control the cytotoxic function of CAR-expressing cells, phospho-proteomic s...

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Identifiers and source

Literature Corpus work
6dc8e629-4657-5ae8-a14c-a3d4469caf12
DOI
10.1101/2022.02.24.481820
Open publication

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Phospho-proteomic analysis of CAR-T cell signaling following activation by antigen-presenting cancer cellsDOI 10.1101/2022.02.24.481820
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