Article

Spatial profiling of CAR protein organization reveals in vivo remodeling during CAR-T therapy

2026-04-22

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy utilizes genetically engineered patient-derived T cells to target cancer cells. Despite its clinical successes in multiple cancer types, the underlying molecular mechanisms by which molecules on CAR-T cells and surrounding cells interact with other proteins and collectively determine treatment efficacy remain elusive. Most previous studies have relied on transcriptome...

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Literature Corpus work: 4d299b1b-4f40-5b9d-9c57-028e2e3e37a3
DOI: 10.64898/2026.04.20.719384

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