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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging

31 Aug 2023

Abstract excerpt

Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that captures heterogeneous spatial protein expression patterns at subcellular resolution. Here we report the extension of IMC to low-abundance markers through incorporation of the DNA-based signal amplification by exchange reaction, immuno-SABER. We applied SABER-IMC to image the tumor immune microenvironment in human melanoma by...

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PMID: 37653118
DOI: 10.1038/s41592-023-01976-y

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