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Article

Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics.

Biophysical journal - 18 Sept 2018

Rohrs Jennifer A, Zheng Dongqing, Graham Nicholas A, Wang Pin, Finley Stacey D

Abstract excerpt

Chimeric antigen receptors (CARs) have recently been approved for the treatment of hematological malignancies, but our lack of understanding of the basic mechanisms that activate these proteins has made it difficult to optimize and control CAR-based therapies. In this study, we use phosphoproteomic mass spectrometry and mechanistic computational modeling to quantify the in vitro kinetics of individual tyrosine...

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Share to CD28 Antigens
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Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30197180
DOI: 10.1016/j.bpj.2018.08.018
PMCID: PMC6139883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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