Article
Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
Human molecular genetics - 1 Aug 2017
Inoshita Tsuyoshi, Arano Taku, Hosaka Yuka, Meng Hongrui, Umezaki Yujiro, Kosugi Sakiko, Morimoto Takako, Koike Masato, Chang Hui-Yun, Imai Yuzuru, Hattori Nobutaka
Abstract excerpt
Mutations of the retromer component Vps35 and endosomal kinase LRRK2 are linked to autosomal dominant forms of familial Parkinson's disease (PD). However, the physiological and pathological roles of Vps35 and LRRK2 in neuronal functions are poorly understood. Here, we demonstrated that the loss of Drosophila Vps35 (dVps35) affects synaptic vesicle recycling, dopaminergic synaptic release and sleep behavior...
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