Article

Parkinson’s disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35

2026-04-13

Abstract excerpt

Mutations in several genes are known to cause familial forms of Parkinson’s disease (PD), including mutations in the vacuolar protein sorting 35 ortholog ( VPS35 ) gene linked to late-onset, autosomal dominant PD. VPS35 encodes a core subunit of the retromer complex which functions in endosomal sorting and recycling. It remains unclear how the pathogenic D620N mutation in VPS35 disrupts retromer function to ind...

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Literature Corpus work: 8c38449e-0ff8-5b39-a3c9-e1a69971e864
DOI: 10.64898/2026.04.09.717005

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