Article

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes

2021-01-17

Abstract excerpt

<h4>Summary</h4> Human antibody responses are established by the generation of combinatorial sequence diversity in antibody variable domains, followed by iterative rounds of mutation and selection via T cell recognition of antigen peptides presented on MHC-II. Here, we report that MHC-II peptide epitope deletion from B cell receptors (BCRs) correlates with antibody development in vivo . Large-scale antibody sequ...

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Literature Corpus work: 6da61add-56fa-566c-b530-0adb1234591d
DOI: 10.1101/2021.01.15.426750

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