Article

Antibody immunogenicity prediction and optimization with ImmunoSeq

2025-08-19

Abstract excerpt

Therapeutic antibody development faces persistent immunogenicity challenges from anti-drug antibodies (ADA). Identifying peptide fragments presented by major histocompatibility complex is the central challenge in predicting immunogenicity. Here, we presented ImmunoSeq, an interpretable and applicable method for immunogenicity prediction. ImmunoSeq addresses this by deploying complementary k-mer (k=8-12) peptide li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3847b5d8-f77f-5bec-a4ce-f5c50da46bb7
DOI: 10.1101/2025.08.14.670305

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody immunogenicity prediction and optimization with ImmunoSeqDOI 10.1101/2025.08.14.670305Read

Data-driven evaluation of suitable immunogens for improved antibody selectionSemantic proximity Read

Immunogenicity of Therapeutic Antibodies: Mechanisms, Prediction, and Mitigation Strategies in the Era of Personalized BiologicsSemantic proximity Read

An in silico method to assess antibody fragment polyreactivitySemantic proximity Read

Fitness Landscape for Antibodies 2: Benchmarking Reveals That Protein AI Models Cannot Yet Consistently Predict Developability PropertiesSemantic proximity Read

An <i>in silico</i> method to assess antibody fragment polyreactivitySemantic proximity Read

Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentationSemantic proximity Read

Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopesSemantic proximity Read

Better antibodies engineered with a GLIMPSE of human dataSemantic proximity Read

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learningSemantic proximity Read

Contextualising the developability risk of antibodies with lambda light chains using enhanced therapeutic antibody profilingSemantic proximity Read

Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody RepertoiresSemantic proximity Read

A general approach for identifying protein epitopes targeted by antibody repertoires using whole proteomesSemantic proximity Read