Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths

Abstract excerpt

B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve e.g. base substitution, codon insertion and deletion, often in association to an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to form, and such studies...

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