Article

siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune response

2019-03-01

Abstract excerpt

We previously reported that small interfering RNA (siRNA) enhances DNA or DNA virus mediated-interferon (IFN)-λ1 induction through retinoic acid-inducible gene I (RIG-I) and interferon gamma-inducible protein 16 (IFI16) crosstalk-signalling pathway. Here we provide further evidence of a new role for siRNA. siRNA containing a 5-nucleotide (nt) motif sequence suppresses DNA-mediated IFNs and inflammatory cytokines....

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Literature Corpus work: 6d930058-8601-57f7-946b-a58680ef973b
DOI: 10.1101/564872

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