Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway

18 Sept 2013

Abstract excerpt

In addition to silencing specific genes, small interfering RNA (siRNA) transfection is also associated with the non-specific induction of inflammatory cytokines and type I interferon. Those so-called "off-target" effects have considerable implications for the interpretation of in vitro studies and clinical application of siRNA. The present study attempted to develop a better understanding of the mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24049081
DOI: 10.1093/nar/gkt844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathwayPMID 24049081Read ↗

siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune responseSemantic proximity Read ↗

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activationSemantic proximity Read ↗

A central role for RNA in the induction and biological activities of type 1 interferonsSemantic proximity Read ↗

Exogenous siRNA Mediates Sequence-Independent Gene Suppression by Signaling through Toll-Like Receptor 3Semantic proximity Read ↗

DSRNA and the Innate Antiviral Immune ResponseSemantic proximity Read ↗

Viral Infections Activate Types I and III Interferon Genes through a Common MechanismSemantic proximity Read ↗

RNA interference and antiviral therapySemantic proximity Read ↗

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune ResponsesSemantic proximity Read ↗

RIG‐I is a key antiviral interferon‐stimulated gene against hepatitis E virus regardless of interferon productionSemantic proximity Read ↗

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAsSemantic proximity Read ↗

Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytesSemantic proximity Read ↗

RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.