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Article

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

3 Sept 2009

Abstract excerpt

Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, immunostimulation by siRNAs may be beneficial in certain therapeutic settings. Various forms of siRNA, meeting different compositional and structural requirements, have been reported to...

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PMID: 19729514
DOI: 10.1093/nar/gkp714

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