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Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA

6 Nov 2013

Abstract excerpt

Mammalian cells have evolved mechanisms to silence foreign DNA introduced by viruses or by transfection. Upon herpesviral infection of cells, the viral genome is chromatinized in an attempt by the host cell to restrict expression of the viral genome. HSV ICP0 acts to counter host-intrinsic and innate responses to viral infection. We have found that nuclear interferon (IFN)-inducible protein 16 (IFI16) acts as a...

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PMID: 24198334
DOI: 10.1073/pnas.1316194110

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