Article
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Cell research - 1 Sept 2012
Yang Zhenlin, Liang Huanhuan, Zhou Qian, Li Ying, Chen Haiwei, Ye Wen, Chen Danying, Fleming Joy, Shu Hongbing, Liu Yingfang
Abstract excerpt
Interferon-stimulated gene 56 (ISG56) family members play important roles in blocking viral replication and regulating cellular functions, however, their underlying molecular mechanisms are largely unclear. Here, we present the crystal structure of ISG54, an ISG56 family protein with a novel RNA-binding structure. The structure shows that ISG54 monomers have 9 tetratricopeptide repeat-like motifs and associate to...
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