Article
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.
Nature communications - 10 Feb 2017
Jønsson K L, Laustsen A, Krapp C, Skipper K A, Thavachelvam K, Hotter D, Egedal J H, Kjolby M, Mohammadi P, Prabakaran T, Sørensen L K, Sun C, Jensen S B, Holm C K, Lebbink R J, Johannsen M, Nyegaard M, Mikkelsen J G, Kirchhoff F, Paludan S R, Jakobsen M R
Abstract excerpt
Innate immune activation by macrophages is an essential part of host defence against infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of interferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING). Other host factors, including interferon-gamma inducible factor 16 (IFI16), have been proposed to contribute to immune...
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