Article

Multi-ancestry fine-mapping of the chromosome 17q12-q21 asthma locus identifies independent associations implicating lymphocyte and eosinophil levels in the causal pathway

2025-08-07

Abstract excerpt

<h4>Background</h4> Asthma pathophysiology varies by age-of-onset and involves diverse immune processes reflected in white blood cell (WBC) subsets. To investigate the genetic architecture of asthma and potential endophenotypes, we analyzed the chr17q12-q21 locus, a robustly replicated asthma locus, across European (EUR), African (AFR), East Asian (EAS), and South Asian (SAS) ancestry groups from the UK Biobank (...

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Literature Corpus work: 6d8f2cbd-1a96-5a10-878b-288f344f0a45
DOI: 10.1101/2025.08.05.25333026

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Multi-ancestry fine-mapping of the chromosome 17q12-q21 asthma locus identifies independent associations implicating lymphocyte and eosinophil levels in the causal pathwayDOI 10.1101/2025.08.05.25333026Read

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