Article

BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesity

2022-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Branched-chain amino acids (BCAAs, including leucine, isoleucine, and valine) have emerged as major players in metabolic health and diseases, but the underlying mechanisms remain obscure. Here, we report that BCAA catabolism drives adipogenesis via an intermediate metabolite of leucine and promotes subcutaneous white adipose tissue (sWAT) expansion during obesity. Genetic analyses of humans and...

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Literature Corpus work: 6d6537bf-d6b6-5f77-bec5-31afd6fe070a
DOI: 10.1101/2022.08.18.504380

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