Article

A cell-autonomous mechanism regulates BCAA catabolism in white adipocytes and systemic metabolic balance

2023-08-01

Abstract excerpt

Elevated plasma branched-chain amino acids (BCAAs) are strongly associated with obesity, insulin resistance (IR), and diabetes in humans and rodent models. However, the mechanisms of BCAA dysregulation and its systemic, organ, and cell-specific implications in the development of obesity and IR are not well understood. To gain mechanistic insight into the causes and effects of plasma BCAA elevations, we leveraged m...

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Literature Corpus work: 7bbd4c80-8f38-5ffd-ad51-e1d79576bf1e
DOI: 10.1101/2023.07.31.551146

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