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Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes.

Diabetes, obesity & metabolism - 1 May 2026

Zhou Xiangyu, Lu Jiawen, Wang Zhenqian, Cheng Kenneth King-Yip, Li Gloria Hoi-Yee

Abstract excerpt

BACKGROUND: Elevated branched-chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β-cell and peripheral insulin resistance. Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear. METHODS: Using publicly available datasets from the European population, we conducted a...

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Amino Acids, Branched-Chain
Insulin
Insulin Resistance
Insulin-Secreting Cells
Insulin Secretion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41705646
DOI: 10.1111/dom.70565
PMCID: PMC13071227

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