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A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

2024-09-09

Abstract excerpt

<h4>Summary</h4> β-hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve interconversion of BHB and primary energy intermediates. Here we show that CNDP2 controls a previously undescribed secondary BHB metabolic pathway via enzymatic conjugation of BHB and free amino acids. This BHB-ylation reaction produces a family of endogenous ketone metabolites, the BHB-amino...

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Literature Corpus work
8bfe8ed4-c40f-503c-a2b6-65beaf528b53
DOI
10.1101/2024.09.09.612087
Open publication

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A secondary β-hydroxybutyrate metabolic pathway linked to energy balanceDOI 10.1101/2024.09.09.612087
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